Legend

CUBIC-HV enables multimodal whole-organ labeling and imaging. a-gChAT (A594) and Dat (A647) double-staining images of the sole Thy1-YFP-H Tg whole adult mouse brain. Voxel size 8.3 × 8.3 × 9 μm³. Top left: Merged image of all three channels. Scale bar: 2 mm. Other panels: Enlarged portions of top left panel. Scale bars: 0.5 mm


Press release

Press release (RIKEN)


Technique

CUBIC-HV


Location

Japan


Citation

Etsuo A. Susaki, Chika Shimizu, Akihiro Kuno, Kazuki Tainaka, Xiang Li, Kengo Nishi, Ken Morishima, Hiroaki Ono, Koji L. Ode, Yuki Saeki, Kazunari Miyamichi, Kaoru Isa, Chihiro Yokoyama, Hiroki Kitaura, Masako Ikemura, Tetsuo Ushiku, Yoshihiro Shimizu, Takashi Saito, Takaomi C. Saido, Masashi Fukayama, Hirotaka Onoe, Kazushige Touhara, Tadashi Isa, Akiyoshi Kakita, Mitsuhiro Shibayama and Hiroki R. Ueda (2020). Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues. Nature Communications 11:1982. DOI:10.1038/s41467-020-15906-5