[Permanent link] [Permanent link] Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline

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Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline

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High throughput, large field of view structural imaging with SCAPE 2.0 Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Shooting stars enlighten intrathalamic plasticity Quadruple whole-cell patch clamp in visual cortex Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline Expression of XFP in the Hippocampus and Cerebral Cortex CLARITY mouse hippocampus Neuronal culture Hippocampal neurons (green) and glial cells (red) Differentiation of cholinergic amacrine cells during chick embryonic development Horizontal cell in piriform cortex of mouse Neurogliaform cell in piriform cortex of mouse Mouse amygdala Simultaneous quadruple patch-clamp recording from layer 5 pyramidal neurons in a cortical brain slice Mouse olfactory bulb P2Y1 receptor localization in the neonatal rat cerebellum Ganglion in the myenteric plexus of a mouse Differentiation of cholinergic amacrine cells during chick embryonic development Cortical neuron culture transfected with EGFP Ex vivo cortical electroporation Mouse embryo axons Immunofluorescent colocalization of Oxytocin and Tyrosine Hydroxylase in the Parventricular Nucleus of a steroid treated hamster Mouse amygdala neurons activated by fear stimulus Brainbow Mouse Hippocampus Brainbow cerebellum Brainbow cortex Brainbow hippocampus (dentate gyrus) Brainbow Mouse Brain Stem
Animated BrainBow CUBIC-HV Fluorescent  × Myelin Populations  × Recording and Manipulation Single Cells Synapses

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Press release

http://www.ru.nl/donders/agenda-news/vm-news/loss-dickkopf-1/


Citation

Seib, D. R., Corsini, N. S., Ellwanger, K., Plaas, C., Mateos, A., Pitzer, C., Nierhs, C., Celikel, T. & Martin-Villalba, A. (2013). Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline. Cell stem cell, 12(2), 204–214