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Micrograph of seven neurons in the rat neonatal neocortex, recorded and stained with a dye. These neurons connect and disconnect from each other spontaneously. When a stimulus is presented, each neuron tends to connect to many more neurons and then prunes weaker connections to settle down to a new circuit configuration.


Citation

Jean-Vincent Le Bé and Henry Markram. Spontaneous and evoked synaptic rewiring in the neonatal neocortex. PNAS Vol. 103 No. 35 (2006) DOI