[Permanent link] [Permanent link] PHF-tau-ir neurons - PV-ir axon terminals

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PHF-tau-ir neurons - PV-ir axon terminals

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Neurons from a mouse spinal cord Signaling in neurons Hippocampal neurons Neurons and Nipah Virus Proteins Zebrafish Locus Coeruleus Hippocampal neuron receiving excitatory contacts Fluorescence image of a neuron labeled for synapses (green) and cell structure (magenta) The axons and dendrites of a cortical neuron Quadruple whole-cell patch clamp in visual cortex Expression of XFP in the Hippocampus and Cerebral Cortex Axons forming a glomerulus in a mouse olfactory bulb Golgi Stained Pyramidal Cell Purkinje neuron in mouse cerebellum Cultured motor neuron (red) on a monolayer of astrocytes Hippocampal neuron expressing monomeric Green Fluorescent Protein Neonatal rat pyramidal neuron PHF-tau-ir neurons - PV-ir axon terminals PHF-tau-ir neurons - chandelier cell axon terminals Hippocampal neuron stained for spectrin (red) and tubulin (green) Neuron transfected with doublecortin (DCX) DsRed and mannose phosphate receptor (MPR) GFP-1 Laser confocal images of neurons in hippocampal slice gene gun transfected with DCX DsRed and μ1A GFP Simultaneous patch-clamp recording from a cortical pyramidal neuron Microelectrode Dye in Purkinje Cell CA1 pyramidal neurons from FVB P12 mouse Neuron transfected with doublecortin (DCX) DsRed and mannose phosphate receptor (MPR) GFP 2 Pyramidal neurons in developing rat visual cortex
Animated BrainBow CUBIC-HV Fluorescent  × Myelin Populations Recording and Manipulation Single Cells  × Synapses

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Legend

(A,B), pairs of confocal images (stacks of 10 optical sections; step size: 1. 04 μm) to illustrate that PV-ir axon terminals (green) are preserved around the somata of PHF-tau-ir neurons (red) in CA1 (patient P7). (D,E), pairs of single confocal sections showing an PHF-tau-ir pyramidal cell (also indicated in (A) with an arrow) to illustrate its perisomatic innervation by PV-ir axon terminals at higher magnification. (G,H), pairs of single confocal sections showing three PV-ir neurons (arrowhead), none of them are labeled for PHF-tau. Panels (C), (F), and (I) were obtained after combining images (A) and (B), (D) and (E), and (G) and (H), respectively. Scale bar: (A.C), 67 μm; (D.I), 43 μm.


Technique

Confocal


Citation

Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients, Lidia Blazquez-Llorca et al., Neuroanatomy 10.3389/fnana.2010.00020 (2010)