[Permanent link] [Permanent link] PHF-tau-ir neurons

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High-power microphotographs to illustrate the morphological appearance of PHF-tau-ir neurons. (A) Pyramidal neuron from the CA1 field of control case C2. (B,C) Pyramidal neurons from the CA2 field of patients P4 and P3, respectively. (D) Pyramidal neuron from the entorhinal cortex of patient P1. (A.C) Correspond to pattern I of PHF-tau staining, which is characterized by a diffuse cytoplasmic staining and the neurons display a normal morphology. (D) Correspond to pattern II of PHF-tau staining, which is characterized by the presence of NFT. These neurons appear to have fewer processes probably due to neuronal atrophy. Scale bar: 37.5 μm.


Citation

Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients, Lidia Blazquez-Llorca et al., Neuroanatomy 10.3389/fnana.2010.00020 (2010)